Reprotest fails to run correctly due to files that are not marked executable: reprotest --verbose --vary=-fileordering,-domain_host,-user_group,-time -c 'date > date' . date -- null WARNING:reprotest:The control build runs on 1 CPU by default, give --min-cpus to increase this. WARNING:reprotest:diffoscope not available, falling back to regular diff INFO:reprotest:STARTING VIRTUAL SERVER ['/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/virt/autopkgtest-virt-null'] Traceback (most recent call last): File "/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/__init__.py", line 862, in run return 0 if check_func(*check_args) else 1 File "/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/__init__.py", line 370, in check proc = test_args._replace(result_dir=result_dir).corun_builds(testbed_args) File "/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/__init__.py", line 114, in start next(cr) File "/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/__init__.py", line 322, in corun_builds with start_testbed(virtual_server_args, temp_dir, no_clean_on_error, File "/gnu/store/50047r6f9chb6dwd01f9hai90y9arwb4-python-3.10.7/lib/python3.10/contextlib.py", line 135, in __enter__ return next(self.gen) File "/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/__init__.py", line 85, in start_testbed testbed.start() File "/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/lib/adt_testbed.py", line 134, in start self.sp = subprocess.Popen(self.vserver_argv, File "/gnu/store/50047r6f9chb6dwd01f9hai90y9arwb4-python-3.10.7/lib/python3.10/subprocess.py", line 969, in __init__ self._execute_child(args, executable, preexec_fn, close_fds, File "/gnu/store/50047r6f9chb6dwd01f9hai90y9arwb4-python-3.10.7/lib/python3.10/subprocess.py", line 1845, in _execute_child raise child_exception_type(errno_num, err_msg, err_filename) PermissionError: [Errno 13] Permission denied: '/gnu/store/7cglj9r39y4hfbwzd3rbh2rgl1yg343v-reprotest-0.7.28/lib/python3.10/site-packages/reprotest/virt/autopkgtest-virt-null' The reprotest version 0.7.21 included in guix v1.4.0 did have these files marked executable, but for some reason in recent versions (maybe changes in pyproject-build-system?), they are shipped without the execute bit set. I have not git bisected between all the versions of guix to see exactly where it starts failing. CCed members of the python team if they have ideas about changes in the build system which might cause the issue. The attached patch marks the necessary files are executable with an added phase. Open to refactorring the patch, but my guile skills are quite limited and this works! live well, vagrant