It supports a subset of mouse behavior via this user setting:

https://support.apple.com/guide/terminal/turn-on-mouse-reporting-trmlc69728a5/2.12/mac/11.0

On Thu, Dec 12, 2024 at 2:16 PM Eli Zaretskii <eliz@gnu.org> wrote:
> From: Filipp Gunbin <fgunbin@fastmail.fm>
> Date: Thu, 12 Dec 2024 20:54:53 +0300
>
> macOS, Terminal.app, xterm-mouse-mode enabled
> emacs -nw -Q
> Select something with mouse, press Command-c
> Try to paste into another program - text is not in the clipboard
>
> Perhaps this is not new, I just tried xterm-mouse-mode for the first
> time, given that it's now the default in master.
>
> Trying different combinations of select-enable-clipboard and
> select-enable-primary did not help (that variables are all I know in
> this area).

Does the macOS Terminal.app support the xterm mouse protocol?