diff --git a/gnu/packages/cross-base.scm b/gnu/packages/cross-base.scm
index ced226ef34..82af27e0b4 100644
--- a/gnu/packages/cross-base.scm
+++ b/gnu/packages/cross-base.scm
@@ -486,6 +486,11 @@ and the cross tool chain."
                    #:xbinutils xbinutils)
       (package
         (inherit libc)
+        (source (origin
+                  (inherit (package-source glibc))
+                  (patches (append (origin-patches (package-source glibc))
+                               (list  (search-patch
+                                       "glibc-powerpc64le-objcopy.patch"))))))
         (name (string-append "glibc-cross-" target))
         (arguments
          (substitute-keyword-arguments
diff --git a/gnu/packages/patches/glibc-powerpc64le-objcopy.patch b/gnu/packages/patches/glibc-powerpc64le-objcopy.patch
new file mode 100644
index 0000000000..acdf29a02a
--- /dev/null
+++ b/gnu/packages/patches/glibc-powerpc64le-objcopy.patch
@@ -0,0 +1,156 @@
+Use "powerpc64le-linux-gnu-objcopy" rather than "objcopy" when cross-compiling
+to powerpc64le-linux-gnu: <https://issues.guix.gnu.org/49417>.
+
+diff --git a/aclocal.m4 b/aclocal.m4
+index 13a791ffde..5b370c07a2 100644
+--- a/aclocal.m4
++++ b/aclocal.m4
+@@ -118,8 +118,6 @@ AS=`$CC -print-prog-name=as`
+ LD=`$CC -print-prog-name=ld`
+ AR=`$CC -print-prog-name=ar`
+ AC_SUBST(AR)
+-OBJCOPY=`$CC -print-prog-name=objcopy`
+-AC_SUBST(OBJCOPY)
+ GPROF=`$CC -print-prog-name=gprof`
+ AC_SUBST(GPROF)
+ 
+diff --git a/configure b/configure
+index fe0eda1cd5..3a08270734 100755
+--- a/configure
++++ b/configure
+@@ -654,7 +654,6 @@ MAKE
+ LD
+ AS
+ GPROF
+-OBJCOPY
+ AR
+ LN_S
+ INSTALL_DATA
+@@ -689,6 +688,7 @@ sysheaders
+ ac_ct_CXX
+ CXXFLAGS
+ CXX
++OBJCOPY
+ OBJDUMP
+ READELF
+ CPP
+@@ -3054,6 +3054,98 @@ else
+   OBJDUMP="$ac_cv_prog_OBJDUMP"
+ fi
+ 
++if test -n "$ac_tool_prefix"; then
++  # Extract the first word of "${ac_tool_prefix}objcopy", so it can be a program name with args.
++set dummy ${ac_tool_prefix}objcopy; ac_word=$2
++{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5
++$as_echo_n "checking for $ac_word... " >&6; }
++if ${ac_cv_prog_OBJCOPY+:} false; then :
++  $as_echo_n "(cached) " >&6
++else
++  if test -n "$OBJCOPY"; then
++  ac_cv_prog_OBJCOPY="$OBJCOPY" # Let the user override the test.
++else
++as_save_IFS=$IFS; IFS=$PATH_SEPARATOR
++for as_dir in $PATH
++do
++  IFS=$as_save_IFS
++  test -z "$as_dir" && as_dir=.
++    for ac_exec_ext in '' $ac_executable_extensions; do
++  if as_fn_executable_p "$as_dir/$ac_word$ac_exec_ext"; then
++    ac_cv_prog_OBJCOPY="${ac_tool_prefix}objcopy"
++    $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5
++    break 2
++  fi
++done
++  done
++IFS=$as_save_IFS
++
++fi
++fi
++OBJCOPY=$ac_cv_prog_OBJCOPY
++if test -n "$OBJCOPY"; then
++  { $as_echo "$as_me:${as_lineno-$LINENO}: result: $OBJCOPY" >&5
++$as_echo "$OBJCOPY" >&6; }
++else
++  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
++$as_echo "no" >&6; }
++fi
++
++
++fi
++if test -z "$ac_cv_prog_OBJCOPY"; then
++  ac_ct_OBJCOPY=$OBJCOPY
++  # Extract the first word of "objcopy", so it can be a program name with args.
++set dummy objcopy; ac_word=$2
++{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5
++$as_echo_n "checking for $ac_word... " >&6; }
++if ${ac_cv_prog_ac_ct_OBJCOPY+:} false; then :
++  $as_echo_n "(cached) " >&6
++else
++  if test -n "$ac_ct_OBJCOPY"; then
++  ac_cv_prog_ac_ct_OBJCOPY="$ac_ct_OBJCOPY" # Let the user override the test.
++else
++as_save_IFS=$IFS; IFS=$PATH_SEPARATOR
++for as_dir in $PATH
++do
++  IFS=$as_save_IFS
++  test -z "$as_dir" && as_dir=.
++    for ac_exec_ext in '' $ac_executable_extensions; do
++  if as_fn_executable_p "$as_dir/$ac_word$ac_exec_ext"; then
++    ac_cv_prog_ac_ct_OBJCOPY="objcopy"
++    $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5
++    break 2
++  fi
++done
++  done
++IFS=$as_save_IFS
++
++fi
++fi
++ac_ct_OBJCOPY=$ac_cv_prog_ac_ct_OBJCOPY
++if test -n "$ac_ct_OBJCOPY"; then
++  { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_ct_OBJCOPY" >&5
++$as_echo "$ac_ct_OBJCOPY" >&6; }
++else
++  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
++$as_echo "no" >&6; }
++fi
++
++  if test "x$ac_ct_OBJCOPY" = x; then
++    OBJCOPY="false"
++  else
++    case $cross_compiling:$ac_tool_warned in
++yes:)
++{ $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: using cross tools not prefixed with host triplet" >&5
++$as_echo "$as_me: WARNING: using cross tools not prefixed with host triplet" >&2;}
++ac_tool_warned=yes ;;
++esac
++    OBJCOPY=$ac_ct_OBJCOPY
++  fi
++else
++  OBJCOPY="$ac_cv_prog_OBJCOPY"
++fi
++
+ 
+ # We need the C++ compiler only for testing.
+ ac_ext=cpp
+@@ -4645,8 +4737,6 @@ AS=`$CC -print-prog-name=as`
+ LD=`$CC -print-prog-name=ld`
+ AR=`$CC -print-prog-name=ar`
+ 
+-OBJCOPY=`$CC -print-prog-name=objcopy`
+-
+ GPROF=`$CC -print-prog-name=gprof`
+ 
+ 
+diff --git a/configure.ac b/configure.ac
+index 924af12738..2148cd2ec8 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -53,6 +53,7 @@ AC_SUBST(cross_compiling)
+ AC_PROG_CPP
+ AC_CHECK_TOOL(READELF, readelf, false)
+ AC_CHECK_TOOL(OBJDUMP, objdump, false)
++AC_CHECK_TOOL(OBJCOPY, objcopy, false)
+ 
+ # We need the C++ compiler only for testing.
+ AC_PROG_CXX
