Hi Arne, I tried to apply your patches but it looks like they are dated or belong to an older commit. After an attempt to build with the fresh "guix pull" all mentioned pckages have built successfully: --8<---------------cut here---------------start------------->8--- ~$ guix build python-aws-xray-sdk python-jose python-kombu python-moto /gnu/store/p77qhfb9d5mlh6qzs1iixi9n08szi2xy-python-aws-xray-sdk-2.14.0 /gnu/store/79fsr2cnhmmsifp4a08iw4mxab4pggjh-python-jose-3.3.0 /gnu/store/dhsn70bxfxd1063yrzj656d5ryp9k0r1-python-kombu-5.3.7 /gnu/store/jw7p8msrzv7zjlj1pyk0h1dsdjlamrmm-python-moto-5.0.25 ~$ guix describe Generation 72 Jan 24 2025 22:18:29 (current) guix ea7a6fa repository URL: https://git.savannah.gnu.org/git/guix.git branch: master commit: ea7a6fa8c66ef3cfd0ccdec6c0a7a3e7ab3dfc9c --8<---------------cut here---------------end--------------->8--- May you check if it's still an issue after "guix pull", and provide on which commit you are, please? -- Thanks, Oleg