This problem seems to be related to the test suite of Elpy upstream, which has been failing for months, consecutively, since 2024 (see https://github.com/jorgenschaefer/elpy/actions?query=workflow%3ATests). Apparently, the project is unmaintained (see https://github.com/jorgenschaefer/elpy): > IMPORTANT NOTE: Looking for a maintainer > > I find myself (@galaunay, current maintainer), unable to maintain Elpy at the moment, and probably for a while. If you are interested in getting involved in Elpy, please contact me by mail, the project definitely needs you ! > > In the meantime, I will keep an eye on the PRs to integrate any fix and/or new features proposed, but I will definitely not be able to treat the issues in a satisfying manner. The last successful emacs-elpy build for x86_64-linux systems in Guix is from September 3, 2024 (see https://ci.guix.gnu.org/search?query=spec%3Amaster+system%3Ax86_64-linux+emacs-elpy). After that, all builds seem to be failing for the same reason: «command "ert-runner" failed with status 255». Maybe emacs-elpy should be removed from Guix? § WORKAROUNDS I wasn't affected until recently because I was using an older revision of Guix where emacs-elpy worked normally. But today I installed emacs-elpy as follows   guix package -i emacs-elpy --without-tests=emacs-elpy So far, it seems to be working fine. If it turns out to fail at some point, I think I'll use the guix time-machine.