Hi!  If you install Trisquel 11 and then install guix with 'sudo apt
install guix' and then do 'guix home reconfigure foo' it will create a
.profile file that sets XCURSOR_PATH which disables system paths.  The
end result is that your mouse cursor is garbled on next login.

This thread seems related, but I think it has to be fixed in guix home
too: https://lists.gnu.org/r/guix-patches/2022-07/msg00096.html

/Simon