Your bug report

#40381: Guix shouldn't request substitutes for profile derivations

which was filed against the guix package, has been closed.

The explanation is attached below, along with your original report.
If you require more details, please reply to 40381@debbugs.gnu.org.

-- 
40381: http://debbugs.gnu.org/cgi/bugreport.cgi?bug=40381
GNU Bug Tracking System
Contact help-debbugs@gnu.org with problems