Hello! The X client versions of GNU Emacs 23.0.x and 23.1.50 do not fail to create a preview when my init file contains '(TeX-PDF-mode t) and they also do not fail when this line is commented. The Cocoa variants of the same versions do all fail when this customisation is set and they do not fail when it not set (commented). Ghostscript 8.61 always succeeds to run, and so do all the utilities used by AUCTeX. The tests were run from auctex-11.85/preview/circ.tex. Systematically the first eqnarray environment (line #67ff) was marked as a region to be previewed. Caching the preamble was always off, except for a last try (which also failed). TeX Live 2008 was last updated a few weeks ago. PdfTeX is an updated version without the font cache bug (which particularly became "famous" for Mac OS X 10.5, Leopard, users). A similar report went to the AUCTeX developers.