Hello, Reporting from the deep trenches of core-updates, I have found this bug: https://gitlab.kitware.com/cmake/cmake/issues/18865 The symptom in Guix is that packages cannot find Boost libraries. A workaround that works for most (all?) packages is adding: #:configure-flags '("-DBoost_NO_BOOST_CMAKE=ON") To disable the use of Boost-provided CMake scripts. CMake already ships with a FindBoost.cmake that works just fine. I don't know what the "proper" fix would be, or whether it is worth a huge rebuild.