Ludo wrote:
Sorry, we’re not seeing this on our builder at
<http://hydra.nixos.org/jobset/gnu/guile-2-0>, which runs
MacOS X 10.2.0.

I believe this problem was introduced with OS X 10.3 (Lion). I was able to compile without any problems until then. Somewhere along the line an OS update removed libltdl breaking guile. When I downloaded a new copy of the library and tried to recompile, I found that the compile was broken.

My compile sequence was:
./configure
make